Foreign Media: Chinese scientists have made a breakthrough in deep brain imaging, achieving high-resolution multi-color two-photon imaging in freely moving mice for the first time.
The research team developed a new type of ultra-broadband hollow-core fiber, allowing the miniature two-photon microscope to transmit femtosecond pulse lasers from 700 to 1060 nanometers, enabling multi-color imaging. This technology can simultaneously capture dynamic three-color images of neural calcium signals, mitochondrial calcium signals, and plaque deposits in the mouse brain, which helps in studying abnormal activities of neurons and mitochondria in the early stages of disease.
In addition, this microscope can achieve neural calcium signal and structural imaging at a depth of more than 820 micrometers without damaging brain tissue, providing new tools for understanding the principles of brain cognition, studying mechanisms of brain diseases, evaluating neuropharmaceuticals, and developing brain-computer interfaces.
Original: www.toutiao.com/article/1841261680076803/
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