IT Home, July 8th report, according to "CAS Voice" today, the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, has for the first time achieved the synthesis of sucrose from methanol by constructing an in vitro biochemical conversion system, breaking through the limitations of relying on natural planting of sugarcane and sugar beets to obtain white sugar.
Previously, the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, had successfully fixed carbon dioxide through chemical methods to synthesize methanol. If further carbon dioxide fixation is carried out, or methanol and other low-carbon molecules are obtained from industrial waste, and then bio-converted into sugar molecules, it would provide a new method of sugar production that does not rely on land cultivation.
In the laboratory, researchers designed and constructed an unnatural pathway for sucrose synthesis, building a magical "molecular production line."
Compared with the natural synthesis pathway, this production line has significant advantages in reaction steps and energy consumption. Researchers further constructed an artificial biochemical conversion system, overcoming the key enzyme rate-limiting bottleneck, achieving the synthesis of sucrose from methanol and other non-grain low-carbon molecules, with product concentration reaching 14g / L.
The Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, stated that this research is not only about the synthesis of sucrose itself, but the in vitro biochemical conversion platform it has built is like a key to open the door to the "artificial sugar world." Researchers have also synthesized low-molecular-weight starch, cellodextrins, and other functional sugars with high product yields, which can be applied in the food and feed industries.
The in vitro biosynthesis system developed by the researchers can be coupled with electrocatalytic / thermal catalytic reduction of carbon dioxide, truly achieving de novo conversion of carbon dioxide into sucrose.
This study takes carbon dioxide as the core raw material, converting carbon dioxide artificially into food and chemicals. In the future, researchers will introduce different enzyme catalysts into the system to synthesize rare sugar molecules in nature that have unique effects, which may have a positive significance for green development.
IT Home provides the paper link:
Original: https://www.toutiao.com/article/7524491058135401011/
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