Foreign Media: Scientists from the University of Rochester have successfully transferred the longevity gene from naked mole-rats into mice, resulting in healthier mice with extended lifespans.
Naked mole-rats may not be visually appealing, but they are among the most closely studied animals in aging research. This small rodent can live up to 41 years—nearly ten times longer than similarly sized rodents—and rarely develop cancer, showing remarkably strong resistance to various age-related diseases.
The research team from the University of Rochester published their study in Nature, reporting that they successfully transplanted a longevity gene from naked mole-rats into mice. The results showed that genetically modified mice experienced a median lifespan extension of approximately 4.4%, along with comprehensive improvements in health. This gene enhances the production of high-molecular-weight hyaluronic acid (HMW-HA), a substance known to fight cancer, reduce inflammation, and support healthy aging.
The study confirms that the unique mechanisms of long-lived species can be transferred to other mammals, offering a new direction for human anti-aging research. The team is now exploring ways to apply this discovery in humans by slowing down HMW-HA degradation or increasing its production.
Original article: toutiao.com/article/1864869151280131/
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