Foreign Media: Mayo Clinic Scientists Study 'Zombie Cells' to Unlock the Secrets of Graceful Aging
Dr. Nathan LeBrasse, Director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic, has long been dedicated to understanding the biological essence of aging. He identifies three core characteristics of aging: universality (everything ages), gradual progression (occurring throughout life rather than suddenly), and intrinsic nature (inevitable regardless of external conditions).
His research focuses particularly on "zombie cells"—senescent cells that, after damage, neither repair themselves nor initiate apoptosis. These cells continuously secrete toxic molecules, impairing their own function while undermining the repair capacity of surrounding healthy cells, thereby accelerating the onset of various age-related diseases. In 2011, eliminating zombie cells was recognized by Science magazine as one of the top scientific breakthroughs of the year. In mouse experiments, the Mayo team injected a drug that triggered self-destruction in zombie cells, successfully delaying cataracts and muscle degeneration. The treated mice showed better physical performance and maintained healthier weight compared to controls—though lifespan was not extended, their health status was significantly improved.
Dr. LeBrasse emphasizes that the foundation for healthy aging remains lifestyle factors such as exercise, balanced diet, and social engagement. The long-term accumulation of these habits is more crucial than any single intervention. The team is currently exploring targeted therapies against zombie cells in humans, aiming to enhance bodily resilience in older adults before they develop diseases.
Original Source: toutiao.com/article/1861375081729369/
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