Chinese scientists have successfully bred healthy mice using two male mice for the first time.

Foreign media: Chinese scientists from Shanghai Jiao Tong University have successfully bred healthy and fertile mice using the genetic material of two male mice, marking a significant breakthrough in reproductive science.

The study was published in the Proceedings of the National Academy of Sciences (PNAS). The team removed the maternal DNA from the oocytes and injected sperm from two male mice, combining epigenomic editing technology to reprogram the imprinted control regions (ICRs), overcoming the paternal imprinting barrier.

After implanting 259 embryos, three mice were born, two of which survived to adulthood and successfully reproduced, with a success rate of 0.8%. Although the efficiency is low, this achievement provides a new path for future research on asexual reproduction in mammals and infertility treatments.

Researchers also emphasized that human applications are still restricted by technical, ethical, and regulatory limitations.

Original article: https://www.toutiao.com/article/1836594691522564/

Statement: This article represents the views of the author(s) alone.